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Prestige Therapy is owned and operated by a husband and wife team who know first hand the trials, tribulations, and joys of raising children with exceptional needs. With this unique experience of having both the professional and special needs family-life knowledge, we have created a therapy clinic environment that prides itself in both convenience and compassion for our clients and their families.

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Ab initio electronic-structure calculations are combined with empirical bond-additivity corrections to yield thermochemical properties of gas-phase molecules. A self-consistent set of heats of formation for molecules in the Si-H, Si-H-Cl, Si-H-F, Si-N-H and Si-NH- F systems is presented, along with preliminary values for some Si-O-C-H species.

Lacin H, Williamson WR, Card GM, Skeath JB, Truman JW. Unc-4 acts to promote neuronal identity and development of the take-off circuit in the Drosophila CNS. Elife. 2020;9:e55007. Published 2020 Mar 27. doi:10.7554/eLife.55007. 2020, Lacin et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

Lacin, Haluk; Williamson, W. Ryan; Card, Gwyneth M.; Skeath, James B.; and Truman, James W., "Unc-4 acts to promote neuronal identity and development of the take-off circuit in the Drosophila CNS." Elife. 9, e55007 (2020). _access_pubs/9341

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11Gene Center of the Ludwig-Maximilians-Universität München, Chair for Molecular Animal Breeding and Biotechnology, Ludwig-Maximilians-Universität München, Feodor-Lynen-Str. 25, 81377 Munich, Germany

Measurement points: (1) palatinal intra-incisor-alveolar point, (2) palatinal-molar-alveolar point, (3) buccal incisor-alveolar point, (4) most inferior point of the Processus condylaris, (5) most superior posterior point of the Processus angularis, (6) most dorsal point of the Foramen magnum at the Os occipitale, and (7) most caudal point of the Os nasale. Mean distance in mm

Cchord static lung compliance, ERV expiratory reserve volume, FEV100 forced expiratory volume, FVC forced vital capacity, IC inspiratory capacity, TLC total lung capacity, VC vital capacity, ns not significant

In addition to the abnormalities observed in patients with MFDA, we found volumetric airflow impairment in our mouse model. Breathing impairment in patients with MFDA was described due to upper airway obstruction without any closer specification (Gordon et al. 2015). We could not clearly detect any morphologic upper airway obstructions in our mouse model by soft-tissue contrast-enhanced micro-CT analysis so far. Nonetheless, female EdnraY129F/+ and EdnraY129F/Y129F mice showed decreased volumetric parameters in lung function analysis. EDNRA caused human cellular airway smooth muscle proliferation when ligated to endothelin (Panettieri et al. 1996, 2008). In tracheostomized E18.5 Ednra-null pups, no changes of respiratory minute volume were observed but decreased ventilatory responses following breathing of hypoxic gas, suggesting that this observation was due to impaired early central respiratory control (Clouthier et al. 1998). Whether breathing impairment observed in MFDA-affected patients and in our mouse model may derive from upper or lower airway defects or both or are due to central defects is still unclear.

Ednra expression was shown for the first time in hair and vibrissal follicles of E15.5 Ednralacz/+ mouse embryos (Gordon et al. 2015). So far, no viable mouse model was available to study the impact of systemic impaired Ednra function on hair development in adult mice. Yet, we did not observe any alopecia in EdnraY129F/+ or EdnraY129F/Y129F mice as reported for MFDA-affected patients. Inherited alopecia is correlated with a number of abnormalities including hormonal factors, alterations of gene transcription factors, impaired morphogenesis of hair follicles, and other cell signaling pathways (Tomann et al. 2016). However, how these and other underlying factors are exactly linked to healthy or aberrant morphology, hair follicle cycling, and subsequently hair loss is still unclear.

We further did not find any cleft palates in the analyzed mice of our cohort so far, as we could not observe any cleft palates in any of all our ENU mutagenesis-derived mouse models (930 mouse lines, unpublished data). Although cleft palates could be induced by triamcinolone in murine C3H strains when administered at E11.5 (Andrew et al. 1973), the C3H background probably is not sufficiently modeling human cleft palates (Juriloff and Harris 2008).

Edn-1 as a ligand of Ednra seems to be a key player for osteoblast differentiation by activating osteoblast signaling pathways, e.g., by activating Wnt signaling in bone (Clines et al. 2007), which additionally was shown by deletion of the Edn-1 receptor (Ednra) in osteoblasts leading to reduced bone mass (Clines et al. 2011). We observed only minor reductions in bone mass in male and female EdnraY129F/+ mice examined between 3 and 12 months of age. However, reductions in bone area and BMC were consistent with reduced body size and normal BMD indicating appropriately bone mass for slightly smaller bones, thus suggesting that the postcranial skeleton was not affected by the mutation.

However, we did not find any cleft palates, hypoplastic eyelids, alopecia, or dental abnormalities. As observed in MFDA-affected individuals, phenotypic outcome in our mouse model resulted in high individual variability of the phenotype. For some observations, a gene-dosage effect could be demonstrated by comparing EdnraY129F/+ with EdnraY129F/Y129F mice.

We thank Anja Wohlbier, Sören Kundt, Lisa Fees, and the team of technical assistants of the GMC for excellent technical assistance. We thank Sandy Lösecke and Susanne Diener for contributing to genetic analysis of the mouse model. We especially thank Sandra Hoffmann and Andreas Mayer for breeding performance of the mouse model, tissue sampling, and genotyping.

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The ARM Mali-G57 MP4 is an integrated mid-range graphics card for ARM based SoCs (mostly Android based). It was introduced late 2020 in the MediaTek Dimensity 800 and uses 4 clusters (hence the MC4/MP4 name).

The ARM Mali-G76 MP10 is an integrated high-end graphics card for ARM based SoCs (mostly Android based). It was introduced in late 2018 in the Kirin 980 (e.g. Mate 20 Pro). It integrates 10 of the 20 possible cores and is based on the second generation of the Bifrost architecture. According to ARM it offers improvements in the machine learning efficiency and a bigger tile buffer for 16x anti-aliasing. Compared to the old Mali-G72, the G76 should offer twice the performance per cluster. Therefore, the G76MP10 should be slightly faster than the G72MP18 e.g. in the Exynos 9810 (Galaxy S9).

Prototyping just got a whole lot easier on QNX! See how our pre-integrated software with support for wireless and wired communications and touch-screen graphics components can move you quickly through the prototyping phase of your next project. Reduce your time to application development, remove your integration headaches, and launch your product faster, with QNX.

The QNX Accelerator Kit is a demonstration and evaluation platform, which is being made freely available for developers and systems integrators for evaluating QNX software. The evaluation platform consists of pre-integrated software components that includes Wifi and Ethernet communications, H.264 and MP4 video, Qt 5.0 and OpenGL ES 2.0 graphics with touch-screen support, custom software that integrates all components, along with the source files necessary to enhance and customize the software. Included with the software are several demo applications that highlight the unique features of the QNX operating system. The accelerator kits are being initially offered on the Freescale i.MX6-based Sabre Lite and the Texas Instruments AM335 Starter Kit boards. 041b061a72


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